Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity

Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity

Wahyu Safriansyah, Endang Juliansyah, Rustaman, Al Arofatus Naini, Kindi Farabi, Mohamad Nurul Azmi, Mohamad Azlan Nafiah, Hadi Kuncoro, Unang Supratman, Sofa Fajriah, Desi Harneti
https://doi.org/10.1080/10286020.2024.2446280

Abstract

Aglaia pachyphylla is a species from the Aglaia genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (1), along with four known compounds (2–5) were isolated from Aglaia pachyphylla Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds 1–5 showed cytotoxic activities against MCF-7 with IC₅₀ values ranging from 160.74 to 299.75 μM.

Keywords:

Meliaceae; Aglaia pachyphylla; Pachyphyllanone; MCF-7; Cytotoxic activity