The research group focuses on isolation of novel bioactive components from terrestrial and marine plants, endophytic fungi, and other sources. Several techniques involved in the research including separation and purification of plants extract using chromatographic techniques including HPLC. The group also put attention on synthesis of organic compounds from class of benzalhydantoin, coumarin, peptide, and others, which are known for their interesting bioactivity or other functional application. The synthesis covers on partial synthesis of natural products and also the analogues. Several syntheses also focus on the development of new reaction that is environmentally friendly, such as the use of nanoparticle catalyst for reduction of carbonyl compound. Computational chemistry approach is also applied to design the molecule, exhibiting better bioactivity or functional properties, as well as to understand the interaction mechanism.