Lansioside E, an onoceranoid-type triterpenoid isolated from the fruit peel of Lansium domesticum Corr. cv. Kokossan and its cytotoxic activity against MCF-7 breast cancer cells

Tri Mayanti, Lutfiah Dwi Ramadhanti, Wahyu Safriansyah,  Darwati,  Nurlelasari, Desi Harneti, Siska Elisahbet Sinaga, Eri Bachtiar, Sri Hartati, Sofa Fajriah, Unang Supratman
https://doi.org/10.1080/10286020.2025.2488314

Abstract

Kokosan is a cultivar of Lansium domesticum (Meliaceae), and compounds in this variant remain limited. A new onoceranoid glycoside, lansioside E (1), along with two known onoceranoids, were isolated from the fruit peels of Kokosan. The structure of the new compound was elucidated based on spectroscopic data, including FTIR, HRTOF-MS, 1D and 2D NMR, NMR calculations (DP4+ analysis). Compounds 1–3 were evaluated for their cytotoxic activity against MCF-7 cells. Compound 3 exhibited the highest potency, with an IC₅₀ value of 17.11 µg/ml, followed by compounds 1 and 2, with IC₅₀ values of 39.83 and 271.90 µg/ml, respectively.

Keywords:

Cytotoxic activity; Lansioside E; Lansium domesticum Corr. cv. Kokossan; MCF-7