Excelxylin A: a new seco A-ring tirucallane triterpenoid from the stem bark of Dysoxylum excelsum

Arsy Kautsari, Al Arofatus Naini, Tri Mayanti, Nurlelasari, Desi Harneti, Kindi Farabi, Rani Maharani, Harizon, Mohamad Nurul Azmi, Unang Supratman
https://doi.org/10.1080/10286020.2024.2329726

Abstract

A new seco-A tirucallane triterpenoid named excelxylin A (1), along with two known seco-A triterpenoids (2–3), were isolated from the n-hexane extract of Dysoxylum excelsum (Spreng.) Blume ex G.Don stem bark. The structure and stereochemistry configuration of compounds 1–3 was established by NMR, IR, and HR-ESI-MS spectroscopic data analyses and comparison of their NMR data with literatures. The compounds exhibited the carbon framework for seco-A ring tirucallane triterpenoid, first reported in the Dysoxylum genus. All compounds were tested for their cytotoxicity against human cervical HeLa cells.

Keywords:

Dysoxylum excelsum; seco-A ring tirucallane; Excelxylin A; Cytotoxic activity