Alliaceumolide A: A rare undescribed 17-membered macrolide from Indonesian Dysoxylum alliaceum

Sandra Amalia Riyadi, Al Arofatus Naini, Tri Mayanti, Kindi Farabi, Desi Harneti, Nurlelasari, Rani Maharani, Ronny Lesmana, Sofa Fajriah, Siriporn Jungsuttiwong, Khalijah Awang, Mohamad Nurul Azmi, Unang Supratman
https://doi.org/10.1016/j.phytol.2024.07.004

Abstract

Alliaceumolide A (1), a new macrolide together with known ivorenolide B (2) were isolated from Dysoxylum alliaceum (Blume) Blume ex A.Juss. These compounds were classified as 17-membered macrolide, which is a rare structure for plant-derived natural products. The structures were elucidated by extensive spectroscopic analyses, and the absolute configuration of 1 was determined by electronic circular dichroism (ECD) using TDDFT method. Furthermore, compounds 1 and 2 were tested for cytotoxic activity against two cancer MCF-7 and HeLa cell lines.

Keywords:

Dysoxylum alliaceum; Meliaceae; Alliaceumolide A; Macrolide; Cytotoxic