A Novel Limonoid from the Seeds of Chisocheton macrophyllus

Nurlelasari, Muhammad Badrul Huda, Wahyu Safriansyah, Unang Supratman, Yudha P. Budiman, Desi Harneti P. Huspa, Rani Maharani, Tri Mayanti, Kindi Farabi, Sofa Fajriah
http://doi.org/10.25135/rnp.451.2311.2960

Abstract

This study aimed to isolate a novel limonoid compound, (6R,7S, 8R, 9R, 10R, 11R, 13S, 17R)-17-(furan-3-yl) -4, 4, 8, 10, 13-pentamethyl-3-oxo-4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17-dodecahydro-3Hcyclopenta[a]phenanthrene-6,7,11triyltriacetate (11α-acetoxydysobinin) (1), and 3 pre-existing limonoids, namely dysobinin (2), dysobinol (3), and 7-deacetylepoxyazadiradione (4) from the seeds of Chisocheton macrophyllus (Meliaceae). In addition, the structure of the isolated compounds was determined using various spectroscopic techniques, including UV, IR, HRTOFMS, 1D, and 2D NMR. The cytotoxic effects of each compound were then evaluated against breast cancer cells of the Michigan Cancer Foundation-7 (MCF-7), but no significant activity was observed.

Keywords:

Chisocheton macrophyllus; Meliaceae; limonoid; cytotoxic activity; MCF-7