Natural Product

Chemistry &

Synthesis

The research focuses on isolation of novel bioactive components from terrestrial and marine plants, endophytic fungi, and other sources. Several techniques involved in the research including separation and purification of plants extract using chromatographic techniques including HPLC. The group also put attention on synthesis of organic compounds from class of benzalhydantoin, coumarin, peptide, and others, which are known for their interesting bioactivity or other functional application. The synthesis covers on partial synthesis of natural products and also the analogues. Several syntheses also focus on the development of new reaction that is environmentally friendly, such as the use of nanoparticle catalyst for reduction of carbonyl compound. Computational chemistry approach is also applied to design the molecule, exhibiting better bioactivity or functional properties, as well as to understand the interaction mechanism.

Selected Publications

Supratman, U., Fujita, T., Akiyama, K., Hayashi, H., Murakami, A., Sakai, H., Koshimizu, K., Ohigashi, H. 2001. Anti-tumor Promoting Activity of Bufadienolides from Kalanchoe pinnata and K. daigremontiana√ó butiflora. Bioscience, biotechnology, and biochemistry, 65(4), 947-949. https://doi.org/10.1271/bbb.65.947

Hidayat, A.T., Farabi, K., Harneti, D., Maharani, R., Mayanti, T., Setiawan, A., Supratman, U. 2017. Cytotoxicity and structure activity relationship of Dammarane-type triterpenoids from the bark of Aglaia elliptica against P-388 murine leukemia cells. Natural Product Sciences, 23(4): 291-298. https://doi.org/10.20307/nps.2017.23.4.291

Herlina, T., Supratman, U., Soedjanaatmadja, M.S., Subarnas, A., Sutardjo, S., Abdullah, N.R., Hayashi, H. 2009. Anti-malarial compound from the stem bark of Erythrina variegata. Indonesian Journal of Chemistry, 181: 112450. https://doi.org/10.22146/ijc.21547

Zainuddin, A., Meilanie, S.R., Darwati, Kurniawan, Nurlelasari, Herlina, T., Saputra, A.R., Al Anshori, J., Mayanti, T. 2020. Cytotoxic Triterpenoids from the Stem Barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 Breast Cancer Cell. Sains Malaysiana, 49(5): 989-994. https://doi.org/10.17576/jsm-2020-4905-03

Hidayat, I-W., Thu, Y.Y., Black, D.S.C., Read, R.W. 2016. CBiological evaluation of certain substituted hydantoins and benzalhydantoins against microbes. IOP Conference Series: Materials Science and Engineering, 107(1): 012058. https://doi.org/10.1088/1757-899X/107/1/012058

Sumiarsa, D., Maharani, R., Zainuddin, A., Hidayat, A.T., Nurhilal, O. 2021. A Pd-NP-AC-catalyzed transfer-hydrogenation of mesityl oxide to methyl isobutyl ketone using sodium formate as hydrogen donor. Egyptian Journal of Chemistry.

Julaeha, E. Puspita, S., Eddy, D.R., Wahyudi, T., Nurzaman, M., Nugaraha, J., Herlina, T., Al Anshori, J. 2021. Microencapsulation of lime (Citrus aurantifolia) oil for antibacterial finishing of cotton fabric. RSC Advances, 11(3): 1734-1749. https://doi.org/10.1039/D0RA09314A

Harneti, D., Tjokronegoro, Safari, A., Supratman, U., Loong, Xe-Min, Mukhtar, M.R., Mohamad, K., Aawang K., Hayashi, H. 2012. Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae). Phytochemistry Letters, 5(3): 496-499. https://doi.org/10.1016/j.phytol.2012.04.013

Mayanti, T., Tjokronegoro, R., Supratman, U. Mukhtar, M.P., Awang, K., Hadi, A.H.A. 2011. Antifeedant triterpenoids from the seeds and bark of Lansium domesticum cv Kokossan (Meliaceae). Molecules, 16(4): 2785-2795. https://doi.org/10.3390/molecules16042785

Nurlelasari, Firdaus, A.R.R., Harneti, D. Indrayati, N., Baroroh, U., Yusuf, M. 2020. Computational study of the potential molecular target for antibreast cancer activity of limonoid derivatives from chisocheton sp. Journal of Applied Pharmaceutical Science, 10(2): 7-12. https://doi.org/10.7324/JAPS.2020.102002

Kurnia, D., Akiyama, K., Hayashi, H. 2008. 29-norcucurbitacin derivatives isolated from the Indonesian medicinal plant, Phaleria macrocarpa (Scheff.) Boerl. Bioscience, biotechnology, and biochemistry, 72(2): 618. https://doi.org/10.1271/bbb.70627

Al Anshori, J., Slanina, T., Palao, E. and Kl√°n, P. 2016. The internal heavy-atom effect on 3-phenylselanyl and 3-phenyltellanyl BODIPY derivatives studied by transient absorption spectroscopy. Photochemical & Photobiological Sciences, 15: 250-259. https://doi.org/10.1039/C5PP00366K

Maharani, R., Brownlee, R.T.C., Hughes, A.B., Abbott, B.M. 2009. . A total synthesis of a highly N-methylated cyclodepsipeptide [2S, 3S-Hmp]-aureobasidin L using solid-phase methods, Tetrahedron, 70(14):2351-2358. https://doi.org/10.1016/j.tet.2014.02.036